By Abigail Klein Leichman - September 21, 2016
Originally appeared here in Israel21c
Israeli and American researchers revealed yesterday that treating a primary breast tumor in lab mice with both genetic therapy and chemotherapy is extremely effective in preventing breast cancer metastasis, the deadly spread of cancerous cells to vital organs.
Results of the breakthrough study were published in the September 19 online issue of Nature Communications by Noam Shomron of Tel Aviv University’s Sackler School of Medicine, Natalie Artzi of the Massachusetts Institute of Technology, Shomron’s students Avital Gilam and Daphna Weissglas, Artzi’s student Joao Conde, and onco-geneticist Prof. Eitan Friedman of Sackler and Chaim Sheba Medical Center at Tel Hashomer.
“Our mission was to block a cancer cell’s ability to change shape and move,” explained Shomron. “Cancer cells alter their cytoskeleton structure in order to squeeze past other cells, enter blood vessels and ride along to their next stop: the lungs, the brain or other vital organs. We chose microRNAs as our naturally occurring therapy, because they are master regulators of gene expression.” Read More